(2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Torrens C, Brawley L, Anthony FW, Dance CS, Dunn R, et al. (2002) Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero. Best Pract Res Clin Endocrinol Metab 22: 155–171.įranco M do C, Dantas AP, Akamine EH, Kawamoto EM, Fortes ZB, et al. NutrNeurosci 7: 201–215.ĭulloo AG (2008) Thrifty energy metabolism in catch-up growth trajectories to insulin and leptin resistance. (2004) A low protein diet causes an increase in the basal levels and variability of mean arterial pressure and heart hate in Fisher rats. Oliveira EL, Cardoso LM, Pedrosa ML, Silva ME, Dun NJ, et al. This review summarizes our current knowledge concerning the role of taurine, TauCl and TauBr in the pathogenesis of inflammatory diseases initiated or. ![]() (2000) Cardiovascular and hypothalamic–pituitary–adrenal axis development in late gestation fetal sheep and young lambs following modest maternal nutrient restriction in early gestation. In contrast to a well-documented regulatory role of taurine and taurine haloamines (TauCl, TauBr) in acute inflammation, their role in the pathogenesis of inflammatory diseases is not clear. Hawkins P, Steyn C, McGarrigle HH, Calder NA, Saito T, et al. The beneficial vascular effect of taurine was associated with restoration of vascular redox homeostasis and improvement of NO bioavailability. Our data indicate a protective role of taurine supplementation on the high blood pressure, endothelial dysfunction and vascular remodeling induced by post-weaning protein restriction. LP rats showed an increased aortic wall/lumen ratio and taurine prevented this remodeling through a reduction in wall media thickness. Taurine supplementation improved the relaxation response to acetylcholine and eNOS-derived NO production, increased EC-SOD and p-eNOS protein expression, as well as reduced ROS generation and p47phox expression in the aortas from LPT rats. Furthermore, ROS production was enhanced while acetylcholine-induced NO release was reduced in aortas from the LP group. Protein expression of p47phox NADPH oxidase subunit was enhanced, whereas extracellular (EC)-SOD and endothelial nitric oxide synthase phosphorylation at Ser 1177 (p-eNOS) were reduced in aortas from LP rats. There was a reduced relaxation response to acetylcholine in isolated thoracic aortic rings from the LP group that was reversed by superoxide dismutase (SOD) or apocynin incubation. LP rats showed elevated systolic, diastolic and mean arterial blood pressure versus NP rats taurine supplementation partially prevented this increase. ![]() Half of the NP and LP rats concomitantly received 2.5% taurine supplementation in the drinking water (NPT and LPT, respectively). Weaned male Wistar rats were fed normal- (12%, NP) or low-protein (6%, LP) diets for 90 days. This study assessed the effects of taurine supplementation in vascular alterations induced by protein restriction in post-weaning rats. Early protein malnutrition reprograms the cardiovascular system and is linked to hypertension in adulthood. Taurine is a sulfur-containing amino acid that exerts protective effects on vascular function and structure in several models of cardiovascular diseases through its antioxidant and anti-inflammatory properties.
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